DD-02 PHARMACODYNAMIC BIOMARKER ASSESSMENTS IN A PHASE I/II TRIAL OF THE HYPOXIA-ACTIVATED PRODRUG TH-302 AND BEVACIZUMAB IN BEVACIZUMAB-REFRACTORY RECURRENT GLIOBLASTOMA

BACKGROUND: Glioblastoma (GBM) remains an incurable malignancy with rapid progression and poor survival. GBM exhibits a hypoxic nature, and treatment with bevacizumab (BEV) may increase intratumoral hypoxia. TH-302 is an investigational prodrug that selectively releases the DNA cross-linker (Br-IPM)...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Cavazos, David, Gruslova, Aleksandra, Sun, J., Floyd, John R., Fichtel, Lisa, Tadi, Surendar, Lodi, Alessia, Tiziani, Stefano, Hart, C.P., Eng, Clarence, Brenner, Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218032/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou246.2
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