Advanced Glycation End-Products Reduce Collagen Molecular Sliding to Affect Collagen Fibril Damage Mechanisms but Not Stiffness

Advanced glycation end-products (AGE) contribute to age-related connective tissue damage and functional deficit. The documented association between AGE formation on collagens and the correlated progressive stiffening of tissues has widely been presumed causative, despite the lack of mechanistic unde...

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Main Authors: Fessel, Gion, Li, Yufei, Diederich, Vincent, Guizar-Sicairos, Manuel, Schneider, Philipp, Sell, David R., Monnier, Vincent M., Snedeker, Jess G.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217736/
https://ncbi.nlm.nih.gov/pubmed/25364829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110948
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