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Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

Interleukin-33 (IL-33) is an alarmin cytokine from the IL-1 family. IL-33 activates many immune cell types expressing the interleukin 1 receptor-like 1 (IL1RL1) receptor ST2, including group-2 innate lymphoid cells (ILC2s, natural helper cells, nuocytes), the major producers of IL-5 and IL-13 during...

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Detalhes bibliográficos
Main Authors: Lefrançais, Emma, Duval, Anais, Mirey, Emilie, Roga, Stéphane, Espinosa, Eric, Cayrol, Corinne, Girard, Jean-Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217470/
https://ncbi.nlm.nih.gov/pubmed/25313073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410700111
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