Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li–Fraumeni cancer predisposition syndrome

The Li–Fraumeni syndrome (LFS) and its variant form (LFL) is a familial predisposition to multiple forms of childhood, adolescent, and adult cancers associated with germ-line mutation in the TP53 tumor suppressor gene. Individual disparities in tumor patterns are compounded by acceleration of cancer...

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Detalhes bibliográficos
Main Authors: Ariffin, Hany, Hainaut, Pierre, Puzio-Kuter, Anna, Choong, Soo Sin, Chan, Adelyne Sue Li, Tolkunov, Denis, Rajagopal, Gunaretnam, Kang, Wenfeng, Lim, Leon Li Wen, Krishnan, Shekhar, Chen, Kok-Siong, Achatz, Maria Isabel, Karsa, Mawar, Shamsani, Jannah, Levine, Arnold J., Chan, Chang S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217424/
https://ncbi.nlm.nih.gov/pubmed/25313051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417322111
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