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Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein

Protein–protein interactions are at the heart of regulatory and signaling processes in the cell. In many interactions, one or both proteins are disordered before association. However, this disorder in the unbound state does not prevent many of these proteins folding to a well-defined, ordered struct...

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Detalles Bibliográficos
Main Authors: Rogers, Joseph M., Oleinikovas, Vladimiras, Shammas, Sarah L., Wong, Chi T., De Sancho, David, Baker, Christopher M., Clarke, Jane
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217413/
https://ncbi.nlm.nih.gov/pubmed/25313042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409122111
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