Obesity accelerates epigenetic aging of human liver

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an “epigenetic clock”) to study the relationship between high body mass index (BMI) and the DNA methylation...

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Bibliografische gegevens
Hoofdauteurs: Horvath, Steve, Erhart, Wiebke, Brosch, Mario, Ammerpohl, Ole, von Schönfels, Witigo, Ahrens, Markus, Heits, Nils, Bell, Jordana T., Tsai, Pei-Chien, Spector, Tim D., Deloukas, Panos, Siebert, Reiner, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Schafmayer, Clemens, Hampe, Jochen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2014
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217403/
https://ncbi.nlm.nih.gov/pubmed/25313081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412759111
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