Obesity accelerates epigenetic aging of human liver

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an “epigenetic clock”) to study the relationship between high body mass index (BMI) and the DNA methylation...

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Main Authors: Horvath, Steve, Erhart, Wiebke, Brosch, Mario, Ammerpohl, Ole, von Schönfels, Witigo, Ahrens, Markus, Heits, Nils, Bell, Jordana T., Tsai, Pei-Chien, Spector, Tim D., Deloukas, Panos, Siebert, Reiner, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Schafmayer, Clemens, Hampe, Jochen
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217403/
https://ncbi.nlm.nih.gov/pubmed/25313081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412759111
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