Obesity accelerates epigenetic aging of human liver

Because of the dearth of biomarkers of aging, it has been difficult to test the hypothesis that obesity increases tissue age. Here we use a novel epigenetic biomarker of aging (referred to as an “epigenetic clock”) to study the relationship between high body mass index (BMI) and the DNA methylation...

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Autori principali: Horvath, Steve, Erhart, Wiebke, Brosch, Mario, Ammerpohl, Ole, von Schönfels, Witigo, Ahrens, Markus, Heits, Nils, Bell, Jordana T., Tsai, Pei-Chien, Spector, Tim D., Deloukas, Panos, Siebert, Reiner, Sipos, Bence, Becker, Thomas, Röcken, Christoph, Schafmayer, Clemens, Hampe, Jochen
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217403/
https://ncbi.nlm.nih.gov/pubmed/25313081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412759111
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