Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor, NMS-P715

Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). While often implicated as a driver of tumor progression and drug resistance, CIN also reduces cell fitness and poses a vulnerability which can be exploited therapeutic...

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Detaylı Bibliyografya
Asıl Yazarlar: Slee, Roger B., Grimes, Brenda R., Bansal, Ruchi, Gore, Jesse, Blackburn, Corinne, Brown, Lyndsey, Gasaway, Rachel, Jeong, Jaesik, Victorino, Jose, March, Keith L., Colombo, Riccardo, Herbert, Brittney-Shea, Korc, Murray
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217310/
https://ncbi.nlm.nih.gov/pubmed/24282275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0324
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