Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic Escherichia coli

Chaperone-usher pathway (CUP) pili are extracellular organelles produced by Gram-negative bacteria that mediate bacterial pathogenesis. Small-molecule inhibitors of CUP pili, termed pilicides, were rationally designed and shown to inhibit type 1 or P piliation. Here, we show that pilicide ec240 decr...

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Bibliographische Detailangaben
Hauptverfasser: Greene, Sarah E., Pinkner, Jerome S., Chorell, Erik, Dodson, Karen W., Shaffer, Carrie L., Conover, Matt S., Livny, Jonathan, Hadjifrangiskou, Maria, Almqvist, Fredrik, Hultgren, Scott J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Microbiology 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217179/
https://ncbi.nlm.nih.gov/pubmed/25352623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02038-14
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