MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer

BACKGROUND: About 70% of all breast cancers are estrogen receptor alpha positive (ER+) and are treated with antiestrogens. However, 50% of ER + tumors develop resistance to these drugs (endocrine resistance). In endocrine resistant cells, an adaptive pathway called the unfolded protein response (UPR...

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Hlavní autoři: Shajahan-Haq, Ayesha N, Cook, Katherine L, Schwartz-Roberts, Jessica L, Eltayeb, Ahreej E, Demas, Diane M, Warri, Anni M, Facey, Caroline O B, Hilakivi-Clarke, Leena A, Clarke, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216870/
https://ncbi.nlm.nih.gov/pubmed/25339305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-239
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