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Predicting Evolutionary Site Variability from Structure in Viral Proteins: Buriedness, Packing, Flexibility, and Design

Several recent works have shown that protein structure can predict site-specific evolutionary sequence variation. In particular, sites that are buried and/or have many contacts with other sites in a structure have been shown to evolve more slowly, on average, than surface sites with few contacts. He...

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Hlavní autoři: Shahmoradi, Amir, Sydykova, Dariya K., Spielman, Stephanie J., Jackson, Eleisha L., Dawson, Eric T., Meyer, Austin G., Wilke, Claus O.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216736/
https://ncbi.nlm.nih.gov/pubmed/25217382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00239-014-9644-x
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