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Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting

[Image: see text] The L3-stage-specific chitinase OvCHT1 has been implicated in the development of Onchocerca volvulus, the causative agent of onchocerciasis. Closantel, a known anthelmintic drug, was previously discovered as a potent and specific OvCHT1 inhibitor. As closantel is also a known proto...

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Bibliografiske detaljer
Main Authors: Gooyit, Major, Tricoche, Nancy, Lustigman, Sara, Janda, Kim D.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216208/
https://ncbi.nlm.nih.gov/pubmed/24918716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5006435
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