Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma

Although the etiology of squamous cell carcinomas of the oral mucosa is well understood, the cellular origin and the exact molecular mechanisms leading to their formation are not. Previously, we observed the coordinated loss of E-cadherin (CDH1) and transforming growth factor beta receptor II (TGFBR...

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Autors principals: Andl, Thomas, Le Bras, Grégoire F., Richards, Nicole F., Allison, Gillian L., Loomans, Holli A., Washington, M.Kay, Revetta, Frank, Lee, Rebecca K., Taylor, Chase, Moses, Harold L., Andl, Claudia D.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Original Manuscript
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216061/
https://ncbi.nlm.nih.gov/pubmed/25233932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu194
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