Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma

Although the etiology of squamous cell carcinomas of the oral mucosa is well understood, the cellular origin and the exact molecular mechanisms leading to their formation are not. Previously, we observed the coordinated loss of E-cadherin (CDH1) and transforming growth factor beta receptor II (TGFBR...

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Bibliographic Details
Main Authors: Andl, Thomas, Le Bras, Grégoire F., Richards, Nicole F., Allison, Gillian L., Loomans, Holli A., Washington, M.Kay, Revetta, Frank, Lee, Rebecca K., Taylor, Chase, Moses, Harold L., Andl, Claudia D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216061/
https://ncbi.nlm.nih.gov/pubmed/25233932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu194
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