Dose Schedule Optimization and the Pharmacokinetic Driver of Neutropenia

Toxicity often limits the utility of oncology drugs, and optimization of dose schedule represents one option for mitigation of this toxicity. Here we explore the schedule-dependency of neutropenia, a common dose-limiting toxicity. To this end, we analyze previously published mathematical models of n...

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Bibliografiske detaljer
Main Authors: Patel, Mayankbhai, Palani, Santhosh, Chakravarty, Arijit, Yang, Johnny, Shyu, Wen Chyi, Mettetal, Jerome T.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215876/
https://ncbi.nlm.nih.gov/pubmed/25360756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109892
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