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Retinal Mitochondrial DNA Mismatch Repair in the Development of Diabetic Retinopathy, and Its Continued Progression After Termination of Hyperglycemia

PURPOSE. Mitochondrial DNA (mtDNA) is damaged in the retina in diabetes, and mitochondria copy numbers are decreased. The displacement-loop (D-loop) of the mtDNA, the region with transcription/replication elements, experiences more damage than other regions of mtDNA. Our aim was to examine the role...

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Detalhes bibliográficos
Main Authors: Mishra, Manish, Kowluru, Renu A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215746/
https://ncbi.nlm.nih.gov/pubmed/25249609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-15020
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