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Retinal Mitochondrial DNA Mismatch Repair in the Development of Diabetic Retinopathy, and Its Continued Progression After Termination of Hyperglycemia

PURPOSE. Mitochondrial DNA (mtDNA) is damaged in the retina in diabetes, and mitochondria copy numbers are decreased. The displacement-loop (D-loop) of the mtDNA, the region with transcription/replication elements, experiences more damage than other regions of mtDNA. Our aim was to examine the role...

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Detalles Bibliográficos
Main Authors: Mishra, Manish, Kowluru, Renu A.
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215746/
https://ncbi.nlm.nih.gov/pubmed/25249609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-15020
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