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RORα Decreases Oxidative Stress Through the Induction of SOD2 and GPx1 Expression and Thereby Protects Against Nonalcoholic Steatohepatitis in Mice

Aims: Increased hepatic oxidative stress and inflammation is the main cause of exacerbating nonalcoholic steatohepatitis (NASH). Retinoic acid-related orphan receptor α (RORα) regulates diverse target genes associated with lipid metabolism, and its expression level is low in the liver of patients wi...

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Detalhes bibliográficos
Main Authors: Han, Yong-Hyun, Kim, Hyeon-Ji, Kim, Eun-Jin, Kim, Kyu-Seo, Hong, Suckchang, Park, Hyeung-Geun, Lee, Mi-Ock
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215383/
https://ncbi.nlm.nih.gov/pubmed/24597775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5655
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