Identification of a Point Mutation Impairing the Binding between Aquaporin-4 and Neuromyelitis Optica Autoantibodies

Neuromyelitis optica (NMO) is characterized by the presence of pathogenic autoantibodies (NMO-IgGs) against supra-molecular assemblies of aquaporin-4 (AQP4), known as orthogonal array of particles (OAPs). NMO-IgGs have a polyclonal origin and recognize different conformational epitopes involving ext...

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Autores principales: Pisani, Francesco, Mola, Maria Grazia, Simone, Laura, Rosito, Stefania, Alberga, Domenico, Mangiatordi, Giuseppe Felice, Lattanzi, Gianluca, Nicolotti, Orazio, Frigeri, Antonio, Svelto, Maria, Nicchia, Grazia Paola
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215237/
https://ncbi.nlm.nih.gov/pubmed/25239624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.582221
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