Conserved active site cysteine residue of archaeal THI4 homolog is essential for thiamine biosynthesis in Haloferax volcanii

BACKGROUND: Thiamine (vitamin B1) is synthesized de novo by certain yeast, fungi, plants, protozoans, bacteria and archaea. The pathway of thiamine biosynthesis by archaea is poorly understood, particularly the route of sulfur relay to form the thiazole ring. Archaea harbor structural homologs of bo...

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Bibliografiska uppgifter
Huvudupphovsmän: Hwang, Sungmin, Cordova, Bryan, Chavarria, Nikita, Elbanna, Dina, McHugh, Stephen, Rojas, Jenny, Pfeiffer, Friedhelm, Maupin-Furlow, Julie A
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215014/
https://ncbi.nlm.nih.gov/pubmed/25348237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12866-014-0260-0
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