Loss of the Podocyte-Expressed Transcription Factor Tcf21/Pod1 Results in Podocyte Differentiation Defects and FSGS

Podocytes are terminally differentiated cells with an elaborate cytoskeleton and are critical components of the glomerular barrier. We identified a bHLH transcription factor, Tcf21, that is highly expressed in developing and mature podocytes. Because conventional Tcf21 knockout mice die in the perin...

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Detalhes bibliográficos
Main Authors: Maezawa, Yoshiro, Onay, Tuncer, Scott, Rizaldy P., Keir, Lindsay S., Dimke, Henrik, Li, Chengjin, Eremina, Vera, Maezawa, Yuko, Jeansson, Marie, Shan, Jingdong, Binnie, Matthew, Lewin, Moshe, Ghosh, Asish, Miner, Jeffrey H., Vainio, Seppo J., Quaggin, Susan E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2014
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214535/
https://ncbi.nlm.nih.gov/pubmed/24904088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013121307
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