Characterization of a Factor H Mutation That Perturbs the Alternative Pathway of Complement in a Family with Membranoproliferative GN

Complement C3 activation is a characteristic finding in membranoproliferative GN (MPGN). This activation can be caused by immune complex deposition or an acquired or inherited defect in complement regulation. Deficiency of complement factor H has long been associated with MPGN. More recently, hetero...

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Detalhes bibliográficos
Main Authors: Wong, Edwin K.S., Anderson, Holly E., Herbert, Andrew P., Challis, Rachel C., Brown, Paul, Reis, Geisilaine S., Tellez, James O., Strain, Lisa, Fluck, Nicholas, Humphrey, Ann, Macleod, Alison, Richards, Anna, Ahlert, Daniel, Santibanez-Koref, Mauro, Barlow, Paul N., Marchbank, Kevin J., Harris, Claire L., Goodship, Timothy H.J., Kavanagh, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2014
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214516/
https://ncbi.nlm.nih.gov/pubmed/24722444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070732
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