Pak1 Is Required to Maintain Ventricular Ca(2+) Homeostasis and Electrophysiological Stability through SERCA2a Regulation in Mice

BACKGROUND: Impaired sarcoplasmic reticular (SR) Ca(2+) uptake resulting from decreased SR Ca(2+)-ATPase type 2a (SERCA2a) expression or activity is characteristic of heart failure (HF) with its associated ventricular arrhythmias. Recent attempts at gene therapy of these conditions explored strategi...

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Détails bibliographiques
Auteurs principaux: Wang, Yanwen, Tsui, Hoyee, Ke, Yunbo, Shi, Ying, Li, Yatong, Davies, Laura, Cartwright, Elizabeth J., Venetucci, Luigi, Zhang, Henggui, Terrar, Derek A., Huang, Christopher L-H., John Solaro, R., Wang, Xin, Lei, Ming
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213946/
https://ncbi.nlm.nih.gov/pubmed/25217043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.113.001198
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