p53-dependent growth arrest of REF52 cells containing newly amplified DNA.
The rat cell line REF52 is not permissive for gene amplification. Simian virus 40 tumor (T) antigen converts these cells to a permissive state, as do dominant negative mutants of p53, suggesting that the effect of T antigen is due mainly to its ability to bind to p53. To manipulate permissivity, we...
Guardat en:
| Publicat a: | Proc Natl Acad Sci U S A |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1995
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42138/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7724543/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.8.3224 |
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