Conformational State Distributions and Catalytically Relevant Dynamics of a Hinge-Bending Enzyme Studied by Single-Molecule FRET and a Coarse-Grained Simulation

Over the last few decades, a view has emerged showing that multidomain enzymes are biological machines evolved to harness stochastic kicks of solvent particles into highly directional functional motions. These intrinsic motions are structurally encoded, and Nature makes use of them to catalyze chemi...

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Detalhes bibliográficos
Main Authors: Gabba, Matteo, Poblete, Simón, Rosenkranz, Tobias, Katranidis, Alexandros, Kempe, Daryan, Züchner, Tina, Winkler, Roland G., Gompper, Gerhard, Fitter, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213667/
https://ncbi.nlm.nih.gov/pubmed/25418172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.08.016
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