Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases

BACKGROUND: Bone metastases arise in nearly 70% of patients with advanced breast cancer, but the complex metastatic process has not been completely clarified yet. RANKL/RANK/OPG pathway modifications and the crosstalk between metastatic cells and bone have been indicated as potential drivers of the...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Arrigoni, Chiara, De Luca, Paola, Gilardi, Mara, Previdi, Sara, Broggini, Massimo, Moretti, Matteo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2014
Aiheet:
Short Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213507/
https://ncbi.nlm.nih.gov/pubmed/25335447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-238
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