BMPRIA is required for osteogenic differentiation and RANKL expression in adult bone marrow mesenchymal stromal cells

Bone morphogenetic proteins (BMPs) activate the canonical Smad1/5/8 and non-canonical Tak1-MAPK pathways via BMP receptors I and II to regulate skeletal development and bone remodeling. Specific ablation of Bmpr1a in immature osteoblasts, osteoblasts, or osteocytes results in an increase in cancello...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Biswas, Soma, Li, Ping, Wu, Hongguang, Shafiquzzaman, Md, Murakami, Shunichi, Schneider, Michael D., Mishina, Yuji, Li, Baojie, Li, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981611/
https://ncbi.nlm.nih.gov/pubmed/29855498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26820-8
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