Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis

BACKGROUND: Accumulating evidence has shown that the inflammatory process participates in the pathogenesis of amyotrophic lateral sclerosis (ALS), suggesting a therapeutic potential of anti-inflammatory agents. Janus kinase 2 (JAK2), one of the key molecules in inflammation, transduces signals downs...

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Bibliografiske detaljer
Main Authors: Tada, Satoru, Okuno, Tatsusada, Hitoshi, Yasumichi, Yasui, Teruhito, Honorat, Josephe Archie, Takata, Kazushiro, Koda, Toru, Shimagami, Hiroshi, Chi-Jing, Choong, Namba, Akiko, Sugimoto, Tomoyuki, Sakoda, Saburo, Mochizuki, Hideki, Kikutani, Hitoshi, Nakatsuji, Yuji
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213500/
https://ncbi.nlm.nih.gov/pubmed/25326688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0179-2
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