Xanthine Oxidase Mediates Axonal and Myelin Loss in a Murine Model of Multiple Sclerosis

OBJECTIVES: Oxidative stress plays an important role in the pathogenesis of multiple sclerosis (MS). Though reactive oxygen species (ROS) are produced by various mechanisms, xanthine oxidase (XO) is a major enzyme generating ROS in the context of inflammation. The objectives of this study were to in...

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Bibliographic Details
Main Authors: Honorat, Josephe Archie, Kinoshita, Makoto, Okuno, Tatsusada, Takata, Kazushiro, Koda, Toru, Tada, Satoru, Shirakura, Takashi, Fujimura, Harutoshi, Mochizuki, Hideki, Sakoda, Saburo, Nakatsuji, Yuji
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738596/
https://ncbi.nlm.nih.gov/pubmed/23951137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071329
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