Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

BACKGROUND: Common genetic variation and rare mutations in genes encoding calcium channel subunits have pleiotropic effects on risk for multiple neuropsychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia. To gain further mechanistic insights by extending previous gene exp...

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Detalhes bibliográficos
Main Authors: Tian, Yuan, Voineagu, Irina, Paşca, Sergiu P, Won, Hyejung, Chandran, Vijayendran, Horvath, Steve, Dolmetsch, Ricardo E, Geschwind, Daniel H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213483/
https://ncbi.nlm.nih.gov/pubmed/25360157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-014-0075-5
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