Pharmacokinetics and Efficacy of the Spleen Tyrosine Kinase Inhibitor R406 after Ocular Delivery for Retinoblastoma

PURPOSE: Retinoblastoma is a childhood cancer of the retina. Clinical trials have shown that local delivery of broad spectrum chemotherapeutic agents is efficacious. Recent studies characterizing the genomic and epigenomic landscape of retinoblastoma identified spleen tyrosine kinase (SYK) as a prom...

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Detalhes bibliográficos
Main Authors: Pritchard, Eleanor M., Stewart, Elizabeth, Zhu, Fangyi, Bradley, Cori, Griffiths, Lyra, Yang, Lei, Suryadevara, Praveen Kumar, Zhang, Jiakun, Freeman, Burgess B., Guy, R. Kiplin, Dyer, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213378/
https://ncbi.nlm.nih.gov/pubmed/24906597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-014-1399-y
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