Soluble LRIG2 Ectodomain Is Released from Glioblastoma Cells and Promotes the Proliferation and Inhibits the Apoptosis of Glioblastoma Cells In Vitro and In Vivo in a Similar Manner to the Full-Length LRIG2

The human leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family contains LRIG1, 2 and 3, encoding integral membrane proteins with an ectodomain, a transmembrane domain and a cytoplasmic tail. LRIG1 negatively regulates multiple receptor tyrosine kinases signaling including the epid...

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Bibliographic Details
Main Authors: Xiao, Qungen, Tan, Yihu, Guo, Yang, Yang, Hongkuan, Mao, Feng, Xie, Ruifan, Wang, Baofeng, Lei, Ting, Guo, Dongsheng
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213030/
https://ncbi.nlm.nih.gov/pubmed/25353163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111419
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