A chemical biology approach identified PI3K as a potential therapeutic target for neurofibromatosis type 2

Mutations in the merlin tumor suppressor gene cause Neurofibromatosis type 2 (NF2), which is a disease characterized by development of multiple benign tumors in the nervous system. The current standard of care for NF2 calls for surgical resection of the characteristic tumors, often with devastating...

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Autori principali: Petrilli, Alejandra M, Fuse, Marisa A, Donnan, Mathew S, Bott, Marga, Sparrow, Nicklaus A, Tondera, Daniel, Huffziger, Julia, Frenzel, Corina, Malany, C Siobhan, Echeverri, Christophe J, Smith, Layton, Fernández-Valle, Cristina
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2014
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212923/
https://ncbi.nlm.nih.gov/pubmed/25360213
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