CD8 and CD4 Epitope Predictions in RV144: No Strong Evidence of a T-Cell Driven Sieve Effect in HIV-1 Breakthrough Sequences from Trial Participants

The modest protection afforded by the RV144 vaccine offers an opportunity to evaluate its mechanisms of protection. Differences between HIV-1 breakthrough viruses from vaccine and placebo recipients can be attributed to the RV144 vaccine as this was a randomized and double-blinded trial. CD8 and CD4...

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Main Authors: Dommaraju, Kalpana, Kijak, Gustavo, Carlson, Jonathan M., Larsen, Brendan B., Tovanabutra, Sodsai, Geraghty, Dan E., Deng, Wenjie, Maust, Brandon S., Edlefsen, Paul T., Sanders-Buell, Eric, Ratto-Kim, Silvia, deSouza, Mark S., Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Pitisuttihum, Punnee, Kaewkungwal, Jaranit, O'Connell, Robert J., Robb, Merlin L., Michael, Nelson L., Mullins, James I., Kim, Jerome H., Rolland, Morgane
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211711/
https://ncbi.nlm.nih.gov/pubmed/25350851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0111334
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