β(2)-Adrenergic Receptor-Dependent Attenuation of Hypoxic Pulmonary Vasoconstriction Prevents Progression of Pulmonary Arterial Hypertension in Intermittent Hypoxic Rats

In sleep apnea syndrome (SAS), intermittent hypoxia (IH) induces repeated episodes of hypoxic pulmonary vasoconstriction (HPV) during sleep, which presumably contribute to pulmonary arterial hypertension (PAH). However, the prevalence of PAH was low and severity is mostly mild in SAS patients, and m...

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Autori principali: Nagai, Hisashi, Kuwahira, Ichiro, Schwenke, Daryl O., Tsuchimochi, Hirotsugu, Nara, Akina, Inagaki, Tadakatsu, Ogura, Sayoko, Fujii, Yutaka, Umetani, Keiji, Shimosawa, Tatsuo, Yoshida, Ken-ichi, Pearson, James T., Uemura, Koichi, Shirai, Mikiyasu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211686/
https://ncbi.nlm.nih.gov/pubmed/25350545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110693
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