A Feasibility Study of Cyclophosphamide, Trastuzumab, and an Allogeneic GM-CSF-secreting Breast Tumor Vaccine for HER-2(+) Metastatic Breast Cancer

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting tumor vaccines are bioactive, but limited by disease burden and immune tolerance. Cyclophosphamide (CY) augments vaccine activity in tolerant neu mice and metastatic breast cancer (MBC) patients. HER-2-specific monoclonal antibodies...

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Autors principals: Chen, G, Gupta, R, Petrik, S, Laiko, M, Leatherman, JM, Asquith, JM, Daphtary, MM, Garrett-Mayer, E, Davidson, NE, Hirt, K, Berg, M, Uram, JN, Dauses, T, Fetting, J, Duus, EM, Atay-Rosenthal, S, Ye, X, Wolff, AC, Stearns, V, Jaffee, EM, Emens, LA
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211036/
https://ncbi.nlm.nih.gov/pubmed/25116755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0058
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