Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

PURPOSE: Granulocyte-macrophage colony-stimulating factor (GM-CSF) –secreting tumor vaccines have demonstrated bioactivity but may be limited by disease burdens and immune tolerance. We tested the hypothesis that cyclophosphamide (CY) and doxorubicin (DOX) can enhance vaccine-induced immunity in pat...

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Bibliographic Details
Main Authors: Emens, Leisha A., Asquith, Justin M., Leatherman, James M., Kobrin, Barry J., Petrik, Silvia, Laiko, Marina, Levi, Joy, Daphtary, Maithili M., Biedrzycki, Barbara, Wolff, Antonio C., Stearns, Vered, Disis, Mary L., Ye, Xiaobu, Piantadosi, Steven, Fetting, John H., Davidson, Nancy E., Jaffee, Elizabeth M.
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2009
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Original Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793039/
https://ncbi.nlm.nih.gov/pubmed/19805669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.23.3494
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