Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

PURPOSE: Granulocyte-macrophage colony-stimulating factor (GM-CSF) –secreting tumor vaccines have demonstrated bioactivity but may be limited by disease burdens and immune tolerance. We tested the hypothesis that cyclophosphamide (CY) and doxorubicin (DOX) can enhance vaccine-induced immunity in pat...

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Detalhes bibliográficos
Main Authors: Emens, Leisha A., Asquith, Justin M., Leatherman, James M., Kobrin, Barry J., Petrik, Silvia, Laiko, Marina, Levi, Joy, Daphtary, Maithili M., Biedrzycki, Barbara, Wolff, Antonio C., Stearns, Vered, Disis, Mary L., Ye, Xiaobu, Piantadosi, Steven, Fetting, John H., Davidson, Nancy E., Jaffee, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2009
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793039/
https://ncbi.nlm.nih.gov/pubmed/19805669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.23.3494
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