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Suvanine Sesterterpenes from a Tropical Sponge Coscinoderma sp. Inhibit Isocitrate Lyase in the Glyoxylate Cycle

The glyoxylate cycle is a sequence of anaplerotic reactions catalyzed by the key enzymes isocitrate lyase (ICL) and malate synthase (MLS). Mutants of Candida albicans lacking ICL are markedly less virulent in mice than the wild-type. Suvanine sesterterpenes (1−9) isolated from a tropical sponge Cosc...

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Detalhes bibliográficos
Main Authors: Lee, So-Hyoung, Won, Tae Hyung, Kim, Heegyu, Ahn, Chan-Hong, Shin, Jongheon, Oh, Ki-Bong
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210890/
https://ncbi.nlm.nih.gov/pubmed/25310766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12105148
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