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Inhibition of phosphodiesterase-4 decreases ethanol intake in mice
RATIONALE: Cyclic AMP (cAMP)-protein kinase A (PKA) signaling has been implicated in the regulation of ethanol consumption. Phosphodiesterase-4 (PDE4) specifically hydrolyzes cAMP and plays a critical role in controlling intracellular cAMP levels in the brain. However, the role of PDE4 in ethanol co...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210373/ https://ncbi.nlm.nih.gov/pubmed/21509503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2290-8 |
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