Activation of diverse signaling pathways by oncogenic PIK3CA mutations

The PIK3CA gene is frequently mutated in human cancers. Here we carry out a SILAC-based quantitative phosphoproteomic analysis using isogenic knockin cell lines containing ‘driver’ oncogenic mutations of PIK3CA to dissect the signaling mechanisms responsible for oncogenic phenotypes induced by mutan...

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Hauptverfasser: Wu, Xinyan, Renuse, Santosh, Sahasrabuddhe, Nandini A., Zahari, Muhammad Saddiq, Chaerkady, Raghothama, Kim, Min-Sik, Nirujogi, Raja S., Mohseni, Morassa, Kumar, Praveen, Raju, Rajesh, Zhong, Jun, Yang, Jian, Neiswinger, Johnathan, Jeong, Jun-Seop, Newman, Robert, Powers, Maureen A., Somani, Babu Lal, Gabrielson, Edward, Sukumar, Saraswati, Stearns, Vered, Qian, Jiang, Zhu, Heng, Vogelstein, Bert, Park, Ben Ho, Pandey, Akhilesh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210192/
https://ncbi.nlm.nih.gov/pubmed/25247763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5961
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