Total Synthesis of Viridicatumtoxin B and Analogues Thereof: Strategy Evolution, Structural Revision, and Biological Evaluation

[Image: see text] The details of the total synthesis of viridicatumtoxin B (1) are described. Initial synthetic strategies toward this intriguing tetracycline antibiotic resulted in the development of key alkylation and Lewis acid-mediated spirocyclization reactions to form the hindered EF spirojunc...

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Main Authors: Nicolaou, K. C., Hale, Christopher R. H., Nilewski, Christian, Ioannidou, Heraklidia A., ElMarrouni, Abdelatif, Nilewski, Lizanne G., Beabout, Kathryn, Wang, Tim T., Shamoo, Yousif
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210137/
https://ncbi.nlm.nih.gov/pubmed/25317739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja506472u
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