Antagonistic functions of LMNA isoforms in energy expenditure and lifespan

Alternative RNA processing of LMNA pre-mRNA produces three main protein isoforms, that is, lamin A, progerin, and lamin C. De novo mutations that favor the expression of progerin over lamin A lead to Hutchinson-Gilford progeria syndrome (HGPS), providing support for the involvement of LMNA processin...

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Detalhes bibliográficos
Main Authors: Lopez-Mejia, Isabel C, de Toledo, Marion, Chavey, Carine, Lapasset, Laure, Cavelier, Patricia, Lopez-Herrera, Celia, Chebli, Karim, Fort, Philippe, Beranger, Guillaume, Fajas, Lluis, Amri, Ez Z, Casas, François, Tazi, Jamal
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210101/
https://ncbi.nlm.nih.gov/pubmed/24639560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338126
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