Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process

How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed that oligodendrocyte precursor cells (OPCs) can be transformed into glioma when mutations are introduced perinatally. However, adult OPCs rarel...

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Main Authors: Galvao, Rui Pedro, Kasina, Anita, McNeill, Robert S., Harbin, Jordan E., Foreman, Oded, Verhaak, Roel G. W., Nishiyama, Akiko, Miller, C. Ryan, Zong, Hui
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210043/
https://ncbi.nlm.nih.gov/pubmed/25246577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414389111
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