Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2

Mutations in the gene encoding ubiquilin2 (UBQLN2) cause amyotrophic lateral sclerosis (ALS), frontotemporal type of dementia, or both. However, the molecular mechanisms are unknown. Here, we show that ALS/dementia-linked UBQLN2(P497H) transgenic mice develop neuronal pathology with ubiquilin2/ubiqu...

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Detalhes bibliográficos
Main Authors: Gorrie, George H., Fecto, Faisal, Radzicki, Daniel, Weiss, Craig, Shi, Yong, Dong, Hongxin, Zhai, Hong, Fu, Ronggen, Liu, Erdong, Li, Sisi, Arrat, Hasan, Bigio, Eileen H., Disterhoft, John F., Martina, Marco, Mugnaini, Enrico, Siddique, Teepu, Deng, Han-Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209984/
https://ncbi.nlm.nih.gov/pubmed/25246588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405741111
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