Orp8 Deficiency in Bone Marrow-Derived Cells Reduces Atherosclerotic Lesion Progression in LDL Receptor Knockout Mice

INTRODUCTION: Oxysterol binding protein Related Proteins (ORPs) mediate intracellular lipid transport and homeostatic regulation. ORP8 downregulates ABCA1 expression in macrophages and cellular cholesterol efflux to apolipoprotein A-I. In line, ORP8 knockout mice display increased amounts of HDL cho...

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Autors principals: van Kampen, Erik, Beaslas, Olivier, Hildebrand, Reeni B., Lammers, Bart, Van Berkel, Theo J. C., Olkkonen, Vesa M., Van Eck, Miranda
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209969/
https://ncbi.nlm.nih.gov/pubmed/25347070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109024
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