PI3Kγ kinase activity is required for optimal T-cell activation and differentiation

Phosphatidylinositol-3-kinase gamma (PI3Kγ) is a leukocyte-specific lipid kinase with signaling function downstream of G protein-coupled receptors to regulate cell trafficking, but its role in T cells remains unclear. To investigate the requirement of PI3Kγ kinase activity in T-cell function, we stu...

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Détails bibliographiques
Auteurs principaux: Ladygina, Nadia, Gottipati, Sridevi, Ngo, Karen, Castro, Glenda, Ma, Jing-Ying, Banie, Homayon, Rao, Tadimeti S, Fung-Leung, Wai-Ping
Format: Artigo
Langue:Inglês
Publié: BlackWell Publishing Ltd 2013
Sujets:
Cellular Immune Response
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209804/
https://ncbi.nlm.nih.gov/pubmed/24030559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343812
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