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Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia
Activation-induced deaminase (AID) is a DNA-mutating enzyme that mediates class-switch recombination as well as somatic hypermutation of antibody genes in B cells. Due to off-target activity, AID is implicated in lymphoma development by introducing genome-wide DNA damage and initiating chromosomal t...
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| Huvudupphovsmän: | , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
BlackWell Publishing Ltd
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4209801/ https://ncbi.nlm.nih.gov/pubmed/24668151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201343853 |
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