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Targeting DNGR-1 (CLEC9A) with antibody/MUC1 peptide conjugates as a vaccine for carcinomas

DCs are the most potent APCs and are the focus of many immunotherapeutic approaches for the treatment of cancer, although most of these approaches require the ex vivo generation and pulsing of DCs. We have targeted a subset of DCs in vivo using an Ab to DNGR-1, a C-type lectin dedicated to the cross...

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Autors principals: Picco, Gianfranco, Beatson, Richard, Taylor-Papadimitriou, Joyce, Burchell, Joy M
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209794/
https://ncbi.nlm.nih.gov/pubmed/24648154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201344076
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