12-hydroxyeicosatetraenoic acid is associated with variability in aspirin-induced platelet inhibition

BACKGROUND: Aspirin is one of the most widely used non-steroidal anti-inflammatory drugs (NSAIDs). It is also a commonly used anti-platelet drug, which inhibits the formation of the platelet activator, thromboxane A(2) (TxA(2)) via inhibition of cyclooxygenase-1 (COX-1). However, the presence of a p...

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Main Authors: Maskrey, Benjamin H, Rushworth, Gordon F, Law, Matthew H, Treweeke, Andrew T, Wei, Jun, Leslie, Stephen J, Megson, Ian L, Whitfield, Phillip D
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4209229/
https://ncbi.nlm.nih.gov/pubmed/25349537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12950-014-0033-4
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