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An anti-platelet agent, OPC-29030, inhibits translocation of 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid production in human platelets

1. In human platelets, arachidonic acid is mainly metabolized by the two enzyme systems; cyclo-oxygenase and 12-lipoxygenase. Cyclo-oxygenase produces prostaglandin H(2) which is further converted to thromboxane B(2). 12-Lipoxygenase synthesizes 12(S)-hydroperoxyeicosatetraenoic acid which is reduce...

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Bibliografische gegevens
Hoofdauteurs: Ozeki, Yasushi, Nagamura, Yoshie, Ito, Hideki, Unemi, Fumiko, Kimura, Yukio, Igawa, Takehiro, Kambayashi, Jun-ichi, Takahashi, Yoshitaka, Yoshimoto, Tanihiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571812/
https://ncbi.nlm.nih.gov/pubmed/10588925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0702976
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